“What I cannot create, I do not understand”, is the famous quote from the physicist Richard Feynman. Building a living cell is clearly one of the most difficult, yet important challenges that lies ahead of us. This exciting Flagship proposal tackles this challenge and will provide a major leap forward in our understanding of what defines life. I fully support this project and its multidisciplinary approach, which will provide Europe with a competitive lead in the fields of synthetic biology and biotechnology.