Anđela Šarić
Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria
About the Šarić Lab
“We are a theoretical and computational physics group that seeks to understand how living cells organise themselves. Our research combines physics, biology, mathematics, and artificial intelligence to uncover the principles that govern how cells grow, move, divide, and function. We develop predictive computer models and collaborate closely with experimental colleagues to test our predictions and inspire new experiments. Our work spans protein self-organisation, cytoskeletal dynamics, membrane remodelling, energy and matter flow, and the origins of cellular complexity. We welcome curious researchers from diverse backgrounds who enjoy interdisciplinary science and are excited to tackle fundamental biological questions using quantitative approaches.”
“We develop physics-based computational models combined with AI approaches to uncover the principles that enable synthetic cells to grow, divide, and replicate. Our goal is to identify the minimal physical mechanisms required for robust cellular reproduction, from cytoskeletal self-organization and membrane remodeling to the coordination of energy and matter flow. By combining modelling with close collaboration with experiment, we aim to guide the design of synthetic cells, interpret experimental observations, and accelerate the discovery of new strategies for building life-like systems from the bottom up.”
For more information, visit the Šarić Lab website or the research group’s page on the ISTA website.
| Main area(s) | Sub-area(s) |
|---|---|
| Synthetic cell division and replication | Minimal contractile cytoskeletons and division rings Condensate-based minimal cell division Minimal chromosome segregation Artificial motility systems DNA partitioning in artificial cells Lipid bilayer fission mechanisms Coacervate-based protocells |