One PhD and two post-doctoral positions in the Niederholtmeyer lab
PhD position on Molecular Evolution in Prebiotic Environments
The Niederholtmeyer lab for Synthetic Biology offers a PhD position within the DFG-funded Collaborative Research Center (CRC) 392 on Molecular Evolution in Prebiotic Environments. The goal of the project is to investigate the evolution of RNA-peptide coacervates harbouring active ribozymes under long-term microfluidic substrate supply. The lab is looking for a PhD student who is enthusiastic about the origins of life, and about working on an interdisciplinary and collaborative project. The ideal candidate has some prior experience with ribozymes, RNA work, microfluidics and/or microscopy. The position can be filled from April 2024.
The Niederholtmeyer lab for Synthetic Biology is currently looking for up to two postdocs to join our collaborative, interdisciplinary team at the TUM Campus Straubing for Biotechnology and Sustainability.
Project 1: Many proteins can spontaneously cluster in molecularly dense, phase-separated liquid-like assemblies, termed biomolecular condensates. Biomolecular condensates are promising as synthetic compartments in cell-free reactions and living cells because they could provide programmable, self-assembled spatial organization and rapidly appear or dissolve on demand. This project uses cell-free synthesis and custom microfluidic tools for the engineering and characterization of biomolecular condensates.
Project 2: Dynamic circuits can control gene expression in time and space. In this project we engineer communication between cell-like compartments to generate self-organizing patterns, similar to what we see during the development of multicellular organisms. To keep cell-like compartments active over time, a microfluidic device maintains optimal conditions for cell-free transcription and translation.